The Syrigos Selini Hotel is located in the center of the Kamari resort community, which has many bars, restaurants, shops, and entertainment options, all of which are located along the waterfront. This particular Santorini hotel is just five minutes from the beach, and most other tourist attractions in town are within walking distances as well. The town of Fira is about 15 minutes from the complex by car, as are the airport and port. The Syrigos Selini Hotel is a 10 to 15-minute drive to the airport and nearest port, making it convenient for both air and sea travel.

The rooms at the Syrigos Selini Hotel include all modern conveniences, including private baths. Televisions, telephones, radio alarms, and tea and coffee making facilities are available as well. Studio apartments can also be rented at this hotel.

Like many of the houses in Santorini, the Syrigos Selini Hotel is situated in a whitewashed building. Parking is available on site.